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The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein. Structure (2008) 16: 842-851 |
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Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity Gene (2009) 431: 23-32 |
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Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12. Appl Environ Microbiol (2009) 75: 1552-1558 |
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Structural and biochemical characteristics of the cyclotide Kalata B5 from Oldenlandia affinis. Biopolymers (2010) 94: 647-658 |
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Isolation and characterization of crotosparsamide, a new cyclic nonapeptide from Croton sparsiflorus Natural product communications (2010) 5: 1885-1888 |
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Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod (2010) 73: 1207-1213 |
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Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae. Phytochemistry (2010) 71: 13-20 |
Breuillin,F., Schramm,J., Hajirezaei,M., Ahkami,A., Favre,P., Druege,U., Hause,B., Bucher,M., Kretzschmar,T., Bossolini,E., Kuhlemeier,C., Martinoia,E., Franken,P., Scholz,U. and Reinhardt,D.
Phosphate systemically inhibits development of arbuscular mycorrhiza in Petunia hybrida and represses genes involved in mycorrhizal functioning. Plant J. (2010) 64: 1002-1017 |
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Revealing impaired pathways in the an11 mutant by high-throughput characterization of Petunia axillaris and Petunia inflata transcriptomes. Plant J. (2011) 68: 11-27 |
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Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. BMC Struct. Biol. (2011) 11: 30-0 |
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Cyclotides from an Extreme Habitat: Characterization of Cyclic Peptides from Viola abyssinica of the Ethiopian Highlands J Nat Prod (2011) [ahead]: 0-0 |
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Optimal Oxidative Folding of the Novel Antimicrobial Cyclotide from Hedyotis biflora Requires High Alcohol Concentrations. Biochemistry (2011) [ahead]: 0-0 |
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The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry (2011) 50: 4077-4086 |
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A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem (2011) 12: 2456-2462 |
Poth AG, Colgrave ML, Philip R, Kerenga B, Daly NL, Anderson MA, Craik DJ
Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 6: 345-355 |
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Discovery of an unusual biosynthetic origin for circular proteins in legumes Proc Natl Acad Sci USA (2011) 108: 10127-10132 |
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Biomedicine in the environment: sorption of the cyclotide kalata B2 to montmorillonite, goethite, and humic acid. Environ. Toxicol. Chem. (2011) 30: 1785-1792 |
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Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J. Biol. Chem. (2011) 286: 44833-44844 |
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Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J. Biol. Chem. (2011) 286: 24275-24287 |
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Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol (2011) 7: 257-259 |
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Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl. Environ. Microbiol. (2011) 77: 8164-8170 |
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Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides (2011) 32: 1719-1723 |
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Analysis of cyclotides in Viola ignobilis by Nano liquid chromatography fourier transform mass spectrometry. Protein Pept. Lett. (2011) 18: 747-752 |
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Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 118: 6709-6717 |
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Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J. Biol. Chem. (2011) 286: 36932-36943 |
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Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo Medicinal Chemistry Research (2014) 23: 1406-1413 |
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Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: isolation, characterization, conformational studies and biological activity. Phytochemistry (2014) 107: 91-96 |
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Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of plant physiology (2015) 178: 17-26 |
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Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells Int J Clin Exp Med (2015) 8: 4059-4065 |
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Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J. Proteome Res. (2015) 14: 4851-4862 |
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Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J. Nat. Prod. (2015) 78: 1073-1082 |
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Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 |
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Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis Proc Natl Acad Sci USA (2016) 113: 3960-3965 |
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A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-rich peptides. Sci Rep (2016) 6: 23005-0 |
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Characterization of a Bioactive Acyclotide from Palicourea rigida Journal of natural products (2016) 79: 2767-2773 |
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Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq Peptide Science (2016) 106: 796-805 |
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Immunostimulating and Gram-negative-specific Antibacterial Cyclotides from the Butterfly Pea Clitoria ternatea. FEBS J (2016) doi:10.1111/febs.13720: 0-0 |
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Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids. J Nat Prod. (2016) 79: 3006-3013 |
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Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells Fitoterapia (2016) 109: 162-168 |
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[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum Journal of natural products (2016) 79: 1454-1458 |
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Cloning and characterization of novel cyclotides genes from South American plants Peptide Science (2016) 106: 784-795 |
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Design of a MCoTI-based cyclotide with angiotensin (1-7)-like activity Molecules (2016) 21: 152-0 |
Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ
Structural and functional characterisation of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies Biopolymers (2016) : 0-0 |
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Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 |
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Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. J Nat Prod. (2017) 80: 1522-1530 |
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Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) DC (Rubiaceae) African health sciences (2017) 17: 827-843 |
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Cyclotides from the indian medicinal plant Viola odorata (Banafsha): Identification and characterization Journal of natural products (2017) 80: 1972-1980 |
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In vivo evaluation of an engineered cyclotide as specific CXCR4 imaging reagent Chemistry–A European Journal (2017) 23: 14469-14475 |
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Stepwise evolution of a buried inhibitor peptide over 45 My Molecular biology and evolution (2017) 34: 1505-1516 |
Hellinger, R., Thell, K., Vasileva, M., Muhammad, T., Gunasekera, S., Kümmel, D., Göransson, U., Becker, C.W. and Gruber, C.W
Chemical proteomics for target discovery of head-to-tail cyclized mini-proteins Frontiers in chemistry (2017) 5: 73-0 |
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W.
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology (2017) 8: 616-0 |
Zou, X.G., Hu, J.N., Li, J., Yang, J.Y., Du, Y.X., Yu, Y.F. and Deng, Z.Y
iCellular uptake of [1–9-NαC]-linusorb B2 and [1–9-NαC]-linusorb B3 isolated from flaxseed, and their antitumor activities in human gastric SGC-7901 cells Journal of Functional Foods (2018) 48: 692-703 |
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How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Frontiers in plant science (2018) 9: 0-0 |
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Biologically active orbitides from the Euphorbiaceae family Planta medica (2018) 84: 558-567 |
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Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. J. Nat. Prod. (2018) 81: 1203-1208 |
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PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata Phytochemistry (2018) 152: 61-70 |
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Discovery and characterization of cyclotides from Rinorea species Journal of natural products (2018) 81: 2512-2520 |
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Targeted delivery of cyclotides via conjugation to a nanobody ACS chemical biology (2018) 13: 2973-2980 |
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Discovery of peptide probes to modulate oxytocin-type receptors of insects Scientific reports (2018) 8: 10020-0 |
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A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Med. (2018) 84: 947-952 |
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Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold International journal of pharmaceutics (2019) 565: 437-446 |
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Viola “inconspicua” No More: An Analysis of Antibacterial Cyclotides Journal of natural products (2019) : 0-0 |
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An orbitide from Ratibida columnifera seed containing 16 amino acid residues Journal of Natural Products (2019) 82: 2152-2158 |
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Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod. (2019) 82: 293-300 |
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Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells International Journal of Food Sciences and Nutrition (2020) : 1-11 |
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Circular permutation of the native enzyme-mediated cyclization position in cyclotides ACS Chemical Biology (2020) 15: 962-969 |
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Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions. J Am Soc Mass Spectrom (2020) 31: 1833-1843 |
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Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions Industrial Crops and Products (2020) 147: 112214-0 |
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Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis. Sci Rep (2020) 10: 12658-0 |
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Cyclic Peptides in Seed of Annona muricata Are Ribosomally Synthesized Journal of Natural Products. (2020) 83: 1167-1173 |
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Evaluation of the <i>in Vivo</i> Aphrodisiac Activity of a Cyclotide Extract from <i>Hybanthus enneaspermus</i>. J Nat Prod (2020) : 0-0 |
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Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb <i>Hybanthus enneaspermus</i>. J Biol Chem (2020) 295: 10911-10925 |
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A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors Nature communications (2020) 11: 1575-0 |
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Exploring the Sequence Diversity of Cyclotides from Vietnamese <i>Viola</i> Species. J Nat Prod (2020) 83: 1817-1828 |
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Behavioral and physiological effects of Viola spp. cyclotides on Myzus persicae (Sulz.) Journal of Insect Physiology (2020) 122: 104025-0 |
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