| References |
| Zhang J, Shu W, Liao B (Unpublished) |
| Levesque MP, Twigg RW, Motley T, Katari MS, Dedhia NN, O'Shaughnessy AL, Balija V, Martienssen RA, McCombie RW, Benfey P, Stevenson D (Unpublished) |
| Levesque MP, Twigg RW, Motley T, Katari MS, Dedhia NN, O'Shaughnessy AL, Balija V, Martienssen RA, McCombie RW, Benfey P, Stevenson D (Unpublished) |
Kaufmann, H.P. and Tobschirbel, A.
Über ein oligopeptid aus leinsamen Chemische Berichte (1959) 92: 2805-2809 |
Wieland T, Faulstich H
Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem (1978) 5: 185-260 |
Goldenberg DP, Creighton TE
Circular and circularly permuted forms of bovine pancreatic trypsin inhibitor. J Mol Biol (1983) 165: 407-13 |
Galvez A, Valdivia E, Maqueda M, Montoya E
Production of bacteriocin-like substances by group D streptococci of human origin. Microbios (1985) 43: 223-32 |
Kosasi S, van der Sluis WG, Boelens R, Hart LA, Labadie RP
Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae): Isolation and sequence determination by means of two-dimensional NMR FEBS lett (1989) 256: 91-96 |
Galvez A, Valdivia E, Martinez M, Maqueda M
Bactericidal action of peptide antibiotic AS-48 against Escherichia coli K-12. Can J Microbiol (1989) 35: 318-21 |
Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T
Bioactive peptides: solid-state and solution conformation of cyclolinopeptide A J Am Chem Soc (1989) 111: 9089-9098 |
Bashwira S, Hootelé C, Tourwé D, Pepermans H, Laus G, Van Binst G
Cleromyrine I, a new cyclohexapeptide from clerodendrum myricoides Tetrahedron (1989) 45: 5845-5852 |
Toba T, Samant SK, Yoshioka E, Itoh T
Reutericin 6, a new bacteriocin produced by Lactobacillus reuteri LA6. Lett Appl Microbiol (1991) 13: 281-6 |
Matsubara Y, Yusa T, Sawabe A, Iizuka Y, Takekuma S, Yoshida Y
Structures of New Cyclic Peptides in Young Unshiu (Citrus unshiu MARCOV.), Orange (Citrus sinensis OSBECK.) and Amanatsu (Citrus natsudaidai) Peelings Agric Biol Chem (1991) 55: 2923-2929 |
Kinoshita K, Tanaka J, Kuroda K, Koyama K, Natori S, Kinoshita T
Cycloleonurinin, a Cyclic Peptide from Leonuri Fructus Chem Pharm Bull (1991) 39: 712-715 |
Tan N-H, Zhou J, Chen C-X, Zhao S-X
Cyclopeptides from the roots of Pseudostellaria heterophylla Phytochemistry (1993) 32: 1327-1330 |
Steven M. Colegate and Russell J. Molyneux
Bioactive natural Products: Detection, Isolation and structural Determination CRC press (1993) : 279-317 |
Schopke T, Hasan Agha MI, Kraft R, Otto A, Hiller K
Hämolytisch aktive komponenten aus Viola tricolor L. und Viola arvensis Murray. [In German] Sci Pharm (1993) 61: 145-53 |
Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M
Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes. J Nat Prod (1994) 57: 1619-25 |
Samyn B, Martinez-Bueno M, Devreese B, Maqueda M, Galvez A, Valdivia E, Coyette J, Van Beeumen J
The cyclic structure of the enterococcal peptide antibiotic AS-48. FEBS Lett (1994) 352: 87-90 |
Morita H, Yun YS, Takeya K, Itokawa H
Segetalin A, a new cyclic hexapeptide from Vaccaria segetalis Tetrahedron Lett (1994) 35: 9593-9596 |
Morita H, Kobata H, Takeya K, Itokawa H
Pseudostellarin G, a new tyrosinase inhibitory cyclic octapeptide from Pseudostellaria heterophylla Tetrahedron Lett (1994) 35: 3563-3564 |
Morita H, Kayashita T, Takeya K, Itokawa H
Conformational analysis of a tyrosinase inhibitory cyclic pentapeptide, pseudostellarin A, from Pseudostellaria heterophylla Tetrahedron (1994) 50: 12599-12608 |
Morita H, Kayashita T, Kobata H, Gonda A, Takeya K, Itokawa H
Pseudostellarins D - F, new tyrosinase inhibitory cyclic peptides from Pseudostellaria heterophylla Tetrahedron (1994) 50: 9975-9982 |
Morita H, Kayashita T, Kobata H, Gonda A, Takeya K, Itokawa H
Pseudostellarins A - C, new tyrosinase inhibitory cyclic peptides from Pseudostellaria heterophylla Tetrahedron (1994) 50: 6797-6804 |
Martinez-Bueno M, Maqueda M, Galvez A, Samyn B, Van Beeumen J, Coyette J, Valdivia E
Determination of the gene sequence and the molecular structure of the enterococcal peptide antibiotic AS-48. J Bacteriol (1994) 176: 6334-9 |
Kawai Y, Saito T, Toba T, Samant SK, Itoh T
Isolation and characterization of a highly hydrophobic new bacteriocin (gassericin A) from Lactobacillus gasseri LA39. Biosci Biotechnol Biochem (1994) 58: 1218-21 |
Gustafson KR, Sowder RC, Henderson LE, Parsons IC, Kashman Y, Cardellina JH, McMahon JB, Buckheit RB, Pannell LK, Boyd MR
Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J Am Chem Soc (1994) 116: 9338-8 |
Zhao Y-R, Zhou J, Wang X-K, Huang X-L, Wu H-M, Zou C
Cyclopeptides from Stellaria yunnanensis Phytochemistry (1995) 40: 1453-1456 |
van den Berg AJ, Horsten SF, Kettenes-van den Bosch JJ, Kroes BH, Beukelman CJ, Leeflang BR, Labadie RP
Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L. FEBS lett (1995) 385: 215-218 |
Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG
Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1. Biochemistry (1995) 34: 4147-58 |
Morita H, Yun YS, Takeya K, Itokawa H, Yamada K
Segetalins B, C and D, three new cyclic peptides from Vaccaria segetalis Tetrahedron (1995) 51: 6003-6014 |
Morita H, Yun YS, Takeya K, Itokawa H, Shiro M
Conformational analysis of a cyclic hexapeptide, segetalin A from Vaccaria segetalis Tetrahedron (1995) 51: 5987-6002 |
Morita H, Kayashita T, Takeya K, Itokawa H, Shiro M
Crystal and solution forms of a cyclic heptapeptide, pseudostellarin D1) Tetrahedron (1995) 51: 12539-12548 |
Morita H, Kayashita T, Takeya K, Itokawa H
Cyclic Peptides from Higher Plants, Part 15, Pseudostellarin H, a New Cyclic Octapeptide from Pseudostellaria heterophylla J Nat Prod (1995) 58: 943-947 |
Li, C., Tan, N., Lu, Y., Liang, H., Mu, Q., Zheng, H., Hao, X. and Zhou, J.
Annomuricatin A, a new cyclopeptide from the seeds of Annona muricata Acta Botanica Yunnanica (1995) 17: 459-462 |
Itokawa H, Yun Y, Morita H, Takeya K, Yamada K
Estrogen-like activity of cyclic peptides from Vaccaria segetalis extracts Planta Med (1995) 61: 561-562 |
Itokawa H, Yun Y, Morita H, Takeya K, Yamada K
Estrogen-like activity of cyclic peptides from Vaccaria segetalis extracts. Planta Med (1995) 61: 561-562 |
Van den Berg AJJ, Horsten SFAJ, Kettenes-van den Bosch JJ, Beukelman CJ, Kroes BH, Leeflang BR, Labadie RP
Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica Phytochemistry (1996) 42: 129-133 |
Morita H, Yun YS, Takeya K, Itokawa H, Shirota O
A cyclic heptapeptide from Vaccaria segetalis Phytochemistry (1996) 42: 439-441 |
Morita H, Kayashita T, Shishido A, Takeya K, Itokawa H, Shiro M
Dichotomins A - E, new cyclic peptides from stellaria dichotoma L. var. lanceolata Bge. Tetrahedron (1996) 52: 1165-1176 |
Morita H, Kayashita T, Shimomura M, Takeya K, Itokawa H
Cyclic Peptides from Higher Plants. 24.1 Yunnanin C, a Novel Cyclic Heptapeptide from Stellaria yunnanensis J Nat Prod (1996) 59: 280-282 |
Horsten SFAJ, van den Berg AJJ, Kettenes-van den Bosch JJ, Leeflang BR, Labadie RP
Cyclogossine A: A Novel Cyclic Heptapeptide Isolated from the Latex of Jatropha gossypifolia Planta Med (1996) 62: 46-50 |
Derua R, Gustafson KR, Pannell LK
Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides. Biochem Biophys Res Commun (1996) 228: 632-8 |
Zhao Y-R, Zhou J, Wang X-K, Wu H-M, Huang X-L, Zou C
Three cyclopeptides from Stellaria delavayi Phytochemistry (1997) 46: 709-714 |
Yun YS, Morita H, Takeya K, Itokawa H
Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis. J Nat Prod (1997) 60: 216-218 |
Morita, H., Shishido, A., Matsumoto, T., Takeya, K., Itokawa, H., Hirano, T. and Oka, K.
A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum Bioorganic & Medicinal Chemistry Letters (1997) 7: 1269-1272 |
Morita H, Yun YS, Takeya K, Itokawa H, Shirota O
Thionation of segetalins A and B, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis Bioorg Med Chem (1997) 5: 631-636 |
Morita H, Yun YS, Takeya K, Itokawa H
Conformation of cyclic heptapeptides: Conformational analysis of segetalins D and E by distance geometry calculations Chem Pharm Bull (1997) 45: 883-887 |
Morita H, Takeya K, Itokawa H
Cyclic octapeptides from Stellaria dichotoma var. lanceolata Phytochemistry (1997) 45: 841-845 |
Morita H, Shishido A, Kayashita T, Takeya K, Itokawa H
Cyclic Peptides from Higher Plants. 39. Dichotomins F and G, Cyclic Peptides from Stellaria dichotoma var. lanceolata J Nat Prod (1997) 60: 404-407 |
Morita H, Kayashita T, Uchida A, Takeya K, Itokawa H
Cyclic Peptides from Higher Plants. 33. Delavayins A−C, Three New Cyclic Peptides from Stellaria delavayi J Nat Prod (1997) 60: 212-215 |
Morita H, Kayashita T, Takeya K, Itokawa H, Shiro M
Conformation of cyclic heptapeptides: solid and solution state conformation of yunnanin A Tetrahedron (1997) 53: 1607-1616 |
Morita H, Gonda A, Takeya k, Itokawa H, Shirota O
Conformational Preferene of Cycloleonuripeptides A, B, and C, Three Proline-Rich Cyclic Nonapeptides from Leonurus heterophyllus Chem Pharm Bull (1997) 45: 161-164 |
Morita H, Gonda A, Takeya K, Itokawa H, Iitaka Y
Cycloleonuripeptide D, a new proline-rich cyclic decapeptide from Leonurus heterophyllus Tetrahedron (1997) 53: 1617-1626 |
Morita H, Gonda A, Takeya k, Itokawa H, Hirano T, Oka K, Shirota O
Solution state conformation of an immunosuppressive cyclic dodecapeptide, cycloleonurinin Tetrahedron (1997) 53: 7469-7478 |
Li C-M, Tan N-H, Mu Q, Zheng H-L, Hao X-J, Wu Y, Zhou J
Cyclopeptide from the seeds of Annona squamosa Phytochemistry (1997) 45: 521-523 |
Auvin-Guette C, Baraguey C, Blond A, Pousset J-L, Bodo B
Cyclogossine B, a Cyclic Octapeptide from Jatropha gossypifolia J Nat Prod (1997) 60: 1155-1157 |
Auvin C, Baraguey C, Blond A, Lezenven F, Pousset J-L, Bodo B
Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin Tetrahedron Lett (1997) 38: 2845-2848 |
Wang Y-C, Tan N-H, Zhou J, Wu H-M
Cyclopeptides from dianthus superbus Phytochemistry (1998) 49: 1453-1456 |
Tam JP, Lu YA
A biomimetic strategy in the synthesis and fragmentation of cyclic protein. Protein Sci (1998) 7: 1583-92 |
Li C-M, Tan N-H, Zheng H-L, Mu Q, Hao X-J, He Y-N, Zhou J
Cyclopeptide from the seeds of Annona muricata Phytochemistry (1998) 48: 555-556 |
Li C-M, Tan N-H, Mu Q, Zheng H-L, Hao X-J, Liang H-L, Zhou J
Cyclopeptides from the seeds of Annona glabra Phytochemistry (1998) 47: 1293-1296 |
Langdon GM, Bruix M, Galvez A, Valdivia E, Maqueda M, Rico M
Sequence-specific 1H assignment and secondary structure of the bacteriocin AS-48 cyclic peptide. J Biomol NMR (1998) 12: 173-5 |
Kawai Y, Saito T, Suzuki M, Itoh T
Sequence analysis by cloning of the structural gene of gassericin A, a hydrophobic bacteriocin produced by Lactobacillus gasseri LA39. Biosci Biotechnol Biochem (1998) 62: 887-92 |
Kawai Y, Saito T, Kitazawa H, Itoh T
Gassericin A; an uncommon cyclic bacteriocin produced by Lactobacillus gasseri LA39 linked at N- and C-terminal ends. Biosci Biotechnol Biochem (1998) 62: 2438-40 |
Baraguey, C., Auvin-Guette, C., Blond, A., Cavelier, F., Lezenven, F., Pousset, J.L. and Bodo, B.
Isolation, structure and synthesis of chevalierins A, B and C, cyclic peptides from the latex of Jatropha chevalieri Journal of the Chemical Society (1998) 1: 3033-3040 |
Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 286: 498-502 |
Tam JP, Lu YA, Yang JL, Chiu KW
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. Proc Natl Acad Sci U S A (1999) 96: 8913-8 |
Morita H, Shishido A, Matsumoto T, Itokawa H, Takeya K
Cyclolinopeptides B - E, new cyclic peptides from Linum usitatissimum Tetrahedron (1999) 55: 967-976 |
Morita H, Sato Y, Kobayashi J
Cyclosquamosins A – G, cyclic peptides from the seeds of Annona squamosa Tetrahedron (1999) 55: 7509-7518 |
Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL
High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds. J Mol Biol (1999) 290: 525-33 |
Li C-M, Tan N-H, Zheng H-L, Mu Q, Hao X-J, He Y-N, Zhou J
Cyclopeptides from the seeds of Annona glabra Phytochemistry (1999) 50: 1047-1052 |
Iwai H, Pluckthun A
Circular beta-lactamase: stability enhancement by cyclizing the backbone. FEBS Lett (1999) 459: 166-72 |
Goransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P
Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod (1999) 62: 283-6 |
Daly NL, Love S, Alewood PF, Craik DJ
Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1. Biochemistry (1999) 38: 10606-14 |
Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ
Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity. J Mol Biol (1999) 285: 333-45 |
Craik DJ, Daly NL, Bond T, Waine C
Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J Mol Biol (1999) 294: 1327-36 |
Camarero JA, Muir TW
Biosynthesis of a Head-to-Tail Cyclized Protein with Improved Biological Activity. J Am Chem Soc (1999) 121: 5597-8 |
Auvin-Guette C, Baraguey C, Blond A, Xavier HS, Pousset J-L, Bodo B
Pohlianins A, B and C, cyclic peptides from the laxes of Jatropha pohliana ssp. molissima Tetrahedron (1999) 55: 11495-11510 |
Hernandez JF, Gagnon J, Chiche L, Nguyen TM, Andrieu JP, Heitz A, Trinh Hong T, Pham TT, Le Nguyen D
Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure. Biochemistry (2000) 39: 5722-30 |
Hallock YF, Sowder RC 2nd, Pannell LK, Hughes CB, Johnson DG, Gulakowski R, Cardellina JH 2nd, Boyd MR
Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa. J Org Chem (2000) 65: 124-8 |
Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR
New circulin macrocyclic polypeptides from Chassalia parvifolia. J Nat Prod (2000) 63: 176-8 |
Gran L, Sandberg F, Sletten K
Oldenlandia affinis (R&S) DC. A plant containing uteroactive peptides used in African traditional medicine. J Ethnopharmacol (2000) 70: 197-203 |
Gonzalez C, Langdon GM, Bruix M, Galvez A, Valdivia E, Maqueda M, Rico M
Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin. Proc Natl Acad Sci U S A (2000) 97: 11221-6 |
Ding Z-T, Zhou J, Tan N-H, Teng R
Two New Cyclic Peptides from Drymaria diandra Planta Med (2000) 66: 386-386 |
Daly NL, Craik DJ
Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1. J Biol Chem (2000) 275: 19068-75 |
Baraguey C, Blond A, Correia I, Pousset J-L, Bodo B, Auvin-Guette C
Mahafacyclin A, a cyclic heptapeptide from Jatropha mahafalensis exhibiting β-bulge conformation Tetrahedron Lett (2000) 41: 325-329 |
Trabi M, Schirra HJ, Craik DJ
Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from Rhesus macaque leukocytes. Biochemistry (2001) 40: 4211-21 |
Stefanowicz, P.
Detection and sequencing of new cyclic peptides from linseed by electrospray ionization mass spectrometry Acta biochimica polonica (2001) 48: 1125-1129 |
Sonnet P, Petit L, Marty D, Guillon J, Rochettea J, Brion J-D
First synthesis of segetalin A and analogous cyclohexapeptides Tetrahedron Lett (2001) 42: 1681-1683 |
Matsumoto T, Shishido A, Morita H, Itokawa H, Takeya K
Cyclolinopeptides F–I, cyclic peptides from linseed Phytochemistry (2001) 57: 251-260 |
Long YQ, Lee SL, Lin CY, Enyedy IJ, Wang S, Li P, Dickson RB, Roller PP
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. Bioorg Med Chem Lett (2001) 11: 2515-9 |
Korsinczky ML, Schirra HJ, Rosengren KJ, West J, Condie BA, Otvos L, Anderson MA, Craik DJ
Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant. J Mol Biol (2001) 311: 579-91 |
Jennings C, West J, Waine C, Craik D, Anderson M
Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis. Proc Natl Acad Sci U S A (2001) 98: 10614-9 |
Heitz A, Hernandez JF, Gagnon J, Hong TT, Pham TT, Nguyen TM, Le-Nguyen D, Chiche L
Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins. Biochemistry (2001) 40: 7973-83 |
Felizmenio-Quimio ME, Daly NL, Craik DJ
Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis. J Biol Chem (2001) 276: 22875-82 |
Craik DJ
Plant cyclotides: circular, knotted peptide toxins. Toxicon (2001) 39: 1809-13 |
Camarero JA, Fushman D, Sato S, Giriat I, Cowburn D, Raleigh DP, Muir TW
Rescuing a destabilized protein fold through backbone cyclization. J Mol Biol (2001) 308: 1045-62 |
Broussalis AM, Goransson U, Coussio JD, Ferraro G, Martino V, Claeson P
First cyclotide from Hybanthus (Violaceae). Phytochemistry (2001) 58: 47-51 |
Bokesch HR, Pannell LK, Cochran PK, Sowder RC 2nd, McKee TC, Boyd MR
A novel anti-HIV macrocyclic peptide from Palicourea condensata. J Nat Prod (2001) 64: 249-50 |
Baraguey, C., Blond, A., Cavelier, F., Pousset, J.L., Bodo, B. and Auvin-Guette, C.
Isolation, structure and synthesis of mahafacyclin B, a cyclic heptapeptide from the latex of Jatropha mahafalensis Journal of the Chemical Society (2001) 1: 2098-2103 |
Zablotna E, Kazmierczak K, Jaskiewicz A, Stawikowski M, Kupryszewski G, Rolka K
Chemical synthesis and kinetic study of the smallest naturally occurring trypsin inhibitor SFTI-1 isolated from sunflower seeds and its analogues. Biochem Biophys Res Commun (2002) 292: 855-9 |
Williams NK, Prosselkov P, Liepinsh E, Line I, Sharipo A, Littler DR, Curmi PM, Otting G, Dixon NE
In vivo protein cyclization promoted by a circularly permuted Synechocystis sp. PCC6803 DnaB mini-intein. J Biol Chem (2002) 227: 7790-8 |
Weiss TM, Yang L, Ding L, Waring AJ, Lehrer RI, Huang HW
Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers. Biochemistry (2002) 41: 10070-6 |
Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME
Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem (2002) 277: 3079-84 |
Skjeldal L, Gran L, Sletten K, Volkman BF
Refined structure and metal binding site of the kalata B1 peptide. Arch Biochem Biophys (2002) 399: 142-8 |
Matsumoto T, Tashiro N, Nishimura K, Takeya K
Conformational analysis of cyclolinopeptides A and B Tetrahedron (2002) 58: 5135-5140 |
Matsumoto T, Tashiro N, Nishimura K, Takeya K
New cyclic peptides from Citrus aurantium Heterocycles (2002) 56: 477-482 |
Matsumoto T, Nishimura K, Takeya K
New Cyclic Peptides from Citrus medica var. sarcodactylis SWINGLE Chem Pharm Bull (2002) 50: 857-860 |
Lindholm P, Goransson U, Johansson S, Claeson P, Gullbo J, Larsson R, Bohlin L, Backlund A
Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther (2002) 1: 365-369 |
Descours A, Moehle K, Renard A, Robinson JA
A new family of beta-hairpin mimetics based on a trypsin inhibitor from sunflower seeds. Chembiochem (2002) 3: 318-23 |
Deechongkit S, Kelly JW
The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain. J Am Chem Soc (2002) 124: 4980-6 |
Craik DJ, Simonsen S, Daly NL
The cyclotides: novel macrocyclic peptides as scaffolds in drug design. Curr Opin Drug Discov Devel (2002) 5: 251-60 |
Bushnell DA, Cramer P, Kornberg RD
Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A (2002) 99: 1218-1222 |
Brauer AB, Kelly G, Matthews SJ, Leatherbarrow RJ
The (1)H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: a minimal canonical loop. J Biomol Struct Dyn (2002) 20: 59-70 |
Svangard E, Goransson U, Smith D, Verma C, Backlund A, Bohlin L, Claeson P
Primary and 3-D modelled structures of two cyclotides from Viola odorata. Phytochemistry (2003) 64: 135-42 |
Sonnet P, Da Nascimento S, Marty D, Franceschini D, Guillon J, Brion J-D, Rochette J
First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity Tetrahedron Lett (2003) 44: 3293-3296 |
Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A
Structure of bacteriocin AS-48: from soluble state to membrane bound state. J Mol Biol (2003) 334: 541-9 |
Rosengren KJ, Daly NL, Plan MR, Waine C, Craik DJ
Twists, knots, and rings in proteins. Structural definition of the cyclotide framework. J Biol Chem (2003) 278: 8606-16 |
Napolitano A, Rodriquez M, Bruno I, Marzocco S, Autore G, Riccio R, Gomez-Paloma L
Synthesis, structural aspects and cytotoxicity of the natural cyclopeptides yunnanins A, C and phakellistatins 1, 10 Tetrahedron (2003) 59: 10203-10211 |
Mu Q, Tang WD, Liu RY, Li CM, Lou LG, Sun HD, Hu CQ
Constituents from the Stems of Goniothalamus griffithii Planta Med (2003) 69: 826-830 |
Marx UC, Korsinczky ML, Schirra HJ, Jones A, Condie B, Otvos L Jr, Craik DJ
Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide. J Biol Chem (2003) 278: 21782-9 |
Kemperman R, Kuipers A, Karsens H, Nauta A, Kuipers O, Kok J
Identification and characterization of two novel clostridial bacteriocins, circularin A and closticin 574. Appl Environ Microbiol (2003) 69: 1589-97 |
Kemperman R, Jonker M, Nauta A, Kuipers OP, Kok J
Functional analysis of the gene cluster involved in production of the bacteriocin circularin A by Clostridium beijerinckii ATCC 25752. Appl Environ Microbiol (2003) 69: 5839-48 |
Kalmokoff ML, Cyr TD, Hefford MA, Whitford MF, Teather RM
Butyrivibriocin AR10, a new cyclic bacteriocin produced by the ruminal anaerobe Butyrivibrio fibrisolvens AR10: characterization of the gene and peptide. Can J Microbiol (2003) 49: 763-73 |
Goransson U, Craik DJ
Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. J Biol Chem (2003) 278: 48188-96 |
Goransson U, Broussalis AM, Claeson P
Expression of Viola cyclotides by liquid chromatography-mass spectrometry and tandem mass spectrometry sequencing of intercysteine loops after introduction of charges and cleavage sites by aminoethylation. Anal Biochem (2003) 318: 107-117 |
Daly NL, Clark RJ, Craik DJ
Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem (2003) 278: 6314-22 |
Barry DG, Daly NL, Clark RJ, Sando L, Craik DJ
Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry (2003) 42: 6688-95 |
Wélé A, Zhang Y, Ndoye I, Brouard JP, Pousset JL, Bodo B
A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola. J Nat Prod (2004) 67: 1577-1579 |
Wélé A, Landon C, Labbé H, Vovelle F, Zhang Y, Bodo B
Sequence and solution structure of cherimolacyclopeptides A and B, novel cyclooctapeptides from the seeds of Annona cherimola Tetrahedron (2004) 60: 405-414 |
Wang C, Zhang L-L, Lu Y, Zheng Q-T, Cheng Y-X, Zhou J, Tan N-H
Study on the spatial structure of brachystemin C, a new cyclic peptide from Brachystemma calycinum J Mol Struct (2004) 688: 67-71 |
Trabi M, Svangard E, Herrmann A, Goransson U, Claeson P, Craik DJ, Bohlin L
Variations in cyclotide expression in viola species. J Nat Prod (2004) 67: 806-10 |
Trabi M, Craik DJ
Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1. Plant Cell (2004) 16: 2204-16 |
Svangard E, Goransson U, Hocaoglu Z, Gullbo J, Larsson R, Claeson P, Bohlin L
Cytotoxic cyclotides from Viola tricolor. J Nat Prod (2004) 67: 144-7 |
Stein T, Dusterhus S, Stroh A, Entian KD
Subtilosin production by two Bacillus subtilis subspecies and variance of the sbo-alb cluster. Appl Environ Microbiol (2004) 70: 2349-53 |
Stefanowicz, P.
Electrospray mass spectrometry and tandem mass spectrometry of the natural mixture of cyclic peptides from linseed European Journal of Mass Spectrometry (2004) 10: 665-671 |
Simonsen SM, Daly NL, Craik DJ
Capped acyclic permutants of the circular protein kalata B1. FEBS Lett (2004) 577: 399-402 |
Ohtsuka K, Kajiki R, Waki M, Nojima T, Takenaka S
Immobilization of sunflower trypsin inhibitor (SFTI-1) peptide onto a gold surface and analysis of its interaction with trypsin. Analyst (2004) 129: 888-9 |
Nourse A, Trabi M, Daly NL, Craik DJ
A comparison of the self-association behavior of the plant cyclotides kalata B1 and kalata B2 via analytical ultracentrifugation. J Biol Chem (2004) 279: 562-70 |
Li CQ, Li BG, Qi HY, Li QL, Wang FP, Zhang GL
Three cyclooctapeptides and one glycoside from Microtoena prainiana. J Nat Prod (2004) 67: 978-982 |
Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC
Structure of Subtilosin A, a Cyclic Antimicrobial Peptide from Bacillus subtilis with Unusual Sulfur to a-Carbon Cross-Links: Formation and Reduction of a-Thio-a-Amino Acid Derivatives. Biochemistry (2004) 43: 3385-95 |
Kawai Y, Kemperman R, Kok J, Saito T
The circular bacteriocins gassericin A and circularin A. Curr Protein Pept Sci (2004) 5: 393-8 |
Kawai Y, Ishii Y, Arakawa K, Uemura K, Saitoh B, Nishimura J, Kitazawa H, Yamazaki Y, Tateno Y, Itoh T, Saito T
Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli. Appl Environ Microbiol (2004) 70: 2906-11 |
Jaulent AM, Leatherbarrow RJ
Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors. Protein Eng Des Sel (2004) 17: 681-7 |
Hsieh PW, Chang FR, Wu CC, Wu KY, Li CM, Chen SL, Wu YC
New cytotoxic cyclic peptides and dianthramide from Dianthus superbus. J Nat Prod (2004) 67: 1522-1527 |
Gustafson KR, McKee TC, Bokesch HR
Anti-HIV cyclotides. Curr Protein Pept Sci (2004) 5: 331-40 |
Goransson U, Svangard E, Claeson P, Bohlin L
Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae. Curr Protein Pept Sci (2004) 5: 317-29 |
Goransson U, Sjogren M, Svangard E, Claeson P, Bohlin L
Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles. J Nat Prod (2004) 67: 1287-90 |
Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ
Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. J Biol Chem (2004) 279: 46858-67 |
Daly NL, Gustafson KR, Craik DJ
The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett (2004) 574: 69-72 |
Colgrave ML, Craik DJ
Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry (2004) 43: 5965-75 |
Buffy JJ, McCormick MJ, Wi S, Waring A, Lehrer RI, Hong M
Solid-state NMR investigation of the selective perturbation of lipid bilayers by the cyclic antimicrobial peptide RTD-1. Biochemistry (2004) 43: 9800-12 |
Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ
Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework. Structure (Camb) (2004) 12: 85-94 |
Abuja PM, Zenz A, Trabi M, Craik DJ, Lohner K
The cyclic antimicrobial peptide RTD-1 induces stabilized lipid-peptide domains more efficiently than its open-chain analogue. FEBS Lett (2004) 566: 301-6 |
Stawikowski M, Stawikowska R, Jaskiewicz A, Zablotna E, Rolka K
Examples of Peptide-Peptoid Hybrid Serine Protease Inhibitors Based on the Trypsin Inhibitor SFTI-1 with Complete Protease Resistance at the P1-P1' Reactive Site. Chembiochem (2005) 6: 1057-61 |
Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Goransson U, Craik DJ
A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell (2005) 17: 3176-89 |
Mulvenna JP, Sando L, Craik DJ
Processing of a 22 kDa Precursor Protein to Produce the Circular Protein Tricyclon A. Structure (Camb) (2005) 13: 691-701 |
Mulvenna JP, Foley FM, Craik DJ.
Discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1. J Biol Chem (2005) 280: 32245-53 |
Korsinczky ML, Clark RJ, Craik DJ
Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry (2005) 44: 1145-53 |
Kamimori H, Hall K, Craik DJ, Aguilar MI
Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance. Anal Biochem (2005) 337: 149-53 |
Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, Waine C, Norman DG, Anderson MA, Craik DJ
Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Mobius strips exist in nature? Biochemistry (2005) 44: 851-60 |
Jaulent AM, Brauer AB, Matthews SJ, Leatherbarrow RJ
Solution structure of a novel C2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1. J Biomol NMR (2005) 33: 57-62 |
Hilpert K, Hansen G, Wessner H, Volkmer-Engert R, Hohne W
Complete substitutional analysis of a sunflower trypsin inhibitor with different serine proteases. J Biochem (Tokyo) (2005) 138: 383-90 |
Craik DJ, Daly NL
Oxidative folding of the cystine knot motif in cyclotide proteins. Protein Pept Lett (2005) 12: 147-52 |
Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ
Isolation and characterisation of novel cyclotides from viola hederaceae: Solution structure and anti-HIV activity of VHL-1, a leaf-specific-expressed cyclotide. J Biol Chem (2005) 280: 22395-405 |
Avrutina O, Schmoldt H, Gabrijelcic-Geiger D, Le Nguyen D, Sommerhoff CP, Diederichsen U, Kolmar H
Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II. Biol Chem (2005) 386: 1301-6 |
Zablotna E, Kret A, Jaskiewicz A, Olma A, Leplawy MT, Rolka K
Introduction of alpha-hydroxymethyamino acid residues in substrate specificity P1 position of trypsin inhibitor SFTI-1 from sunflower seeds retains its activity. Biochem Biophys Res Commun (2006) 340: 823-8 |
Thongyoo P, Tate EW, Leatherbarrow, RJ
Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. Chem Commun (2006) 27: 2848-2850 |
Morita H, Eda M, Iizuka T, Hirasawa Y, Sekiguchi M, Yun YS, Itokawa H, Takeya K
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis. Bioorg Med Chem Lett (2006) 16: 4458-4461 |
Mongkolvisut, W., Sutthivaiyakit, S., Leutbecher, H., Mika, S., Klaiber, I., Möller, W., Rösner, H., Beifuss, U. and Conrad, J.
Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima Journal of natural products (2006) 69: 1435-1441 |
Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ
Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins. J Mol Biol (2006) 357: 1522-35 |
Ireland DC, Colgrave ML, Craik DJ
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. Biochem J. (2006) 400: 1-12 |
Herrmann A, Svangard E, Claeson P, Gullbo J, Bohlin L, Goransson U
Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2. Cell Mol Life Sci (2006) 63: 235-45 |
Guo X, Shi J, Tang Z, Cui D, Zhang Y
Synthesis and biological activity of seleno sunflower trypsin inhibitor analog. Chem Biol Drug Des (2006) 68: 341-4 |
Daly NL, Clark RJ, Plan MR, Craik DJ
Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J (2006) 393: 619-26 |
Daly NL, Chen YK, Foley FM, Bansal PS, Bharathi R, Clark RJ, Sommerhoff CP, Craik DJ
The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold J Biol Chem (2006) 281: 23668-75 |
Clark RJ, Daly NL, Craik DJ
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J (2006) 394: 85-93 |
Chen B, Colgrave ML, Wang C, Craik DJ
Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. J Nat Prod (2006) 69: 23-8 |
Cemazar M, Daly NL, Häggblad S, Lo KP, Yulyaningsih E, Craik DJ
Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate. J Biol Chem (2006) 281(12):8224-32: 8224-8232 |
Wirawan RE, Swanson KM, Kleffmann T, Jack RW, Tagg JR
Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology (2007) 153: 1619-30 |
Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Göransson U, Craik DJ
Anti-HIV Cyclotides from the CHinese Medicinal Herb Viola yedoensis J Nat Prod (2007) 71: 47-52 |
Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow, RJ
Immobilized protease-assisted sysnthesis of engineered cysteine-knot microproteins Chembiochem (2007) 8: 1107-1109 |
Svangard E, Burman R, Gunasekera S, Lovborg H, Gullbo J, Goransson U
Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes. J Nat Prod (2007) 70: 643-647 |
Shimamura,K., Ishimizu,T., Nishimura,K., Matsubara,K., Kodama,H., Watanabe,H., Hase,S. and Ando,T.
Analysis of expressed sequence tags from petunia flowers Plant Sci. (2007) 173: 495-500 |
Seydel P, Gruber CW, Craik DJ, Dörnenburg H
Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures. Appl Microbiol Biotechnol. (2007) 77: 275-284 |
Quintyne-Walcott, S., Maxwell, A.R. and Reynolds, W.F.
Crotogossamide, a cyclic nonapeptide from the latex of Croton gossypifolius Journal of natural products (2007) 70: 1374-1376 |
Plan MR, Goransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ
The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides Chembiochem (2007) 8: 1001-1011 |
Jiang S, Li P, Lee SL, Lin CY, Long YQ, Johnson MD, Dickson RB, Roller PP
Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase. Org Lett (2007) 9: 9-12 |
Hallen HE, Luo H, Scott-Craig JS, Walton JD
Gene family encoding the major toxins of lethal Amanita mushrooms Proc Natl Acad Sci U S A (2007) 104: 19097-19101 |
Simonsen SM, Sando L, Rosengren KJ, Wang CK, Colgrave ML, Daly NL, Craik DJ
Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity J Biol Chem (2008) 283: 9805-9813 |
Shenkarev ZO, Nadezhdin KD, Sobol VA, Sobol AG, Skjeldal L, Arseniev AS.
Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle. FEBS J (2008) 273: 2658-2672 |
Shenkarev ZO, Nadezhdin KD, Lyukmanova EN, Sobol VA, Skjeldal L, Arseniev AS
Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelle. J Inorg Biochem (2008) 102: 1246-1256 |
Plan MR, Saska I, Cagauan AG, Craik DJ
Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail) J Agric Food Chem (2008) 56: 5237-5241 |
Mozoruk J, Hunnicutt LE, Hunter WB, Bausher MG
CsV03-3 is a member of a novel gene family from citrus that encodes a protein with DNA binding activity and whose expression is responsive to defense signals and abiotic stress. J Plant Physiol (2008) 165: 531-543 |
Martin-Visscher,L.A., van Belkum,M.J., Garneau-Tsodikova,S., Whittal,R.M., Zheng,J., McMullen,L.M. and Vederas,J.C.
Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl. Environ. Microbiol. (2008) 74: 4756-4763 |
Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ
Cyclotides as natural anti-HIV agents Biopolymers (2008) 90: 51-60 |
Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Goransson U
The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity Phytochemistry (2008) 69: 939-952 |
Gruber CW, Elliott AG, Ireland DC, Delprete PG, Dessein S, Göransson U, Trabi M, Wang CK, Kinghorn AB, Robbrecht E, Craik DJ
Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 20: 2471-2483 |
Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME
Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun (2008) 76: 5853-5891 |
Colgrave ML, Kotze AC, Ireland DC, Wang CK, Craik DJ
The anthelmintic activity of the cyclotides: natural variants with enhanced activity Chembiochem (2008) 9: 1939-1945 |
Colgrave ML, Kotze AC, Huang YH, O'Grady J, Simonsen SM, Craik DJ.
Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry (2008) 47: 5581-5589 |
Cemazar M, Joshi A, Daly NL, Mark AE, Craik DJ
The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein. Structure (2008) 16: 842-851 |
Brueckner F, Cramer P
Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation. Nat Struct Mol Biol (2008) 15: 811-818 |
Barbeta BL, Marshall AT, Gillon AD, Craik DJ, Anderson MA
Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae Proc Natl Acad Sci U S A (2008) 105: 1221-1225 |
Zhang J, Liao B, Craik DJ, Li J-T, Hu M, Shu W
Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity Gene (2009) 431: 23-32 |
Wang CK, Hu SH, Martin JL, Sjögren T, Hajdu J, Bohlin L, Claeson P, Göransson U, Rosengren KJ, Tang J, Tan NH, Craik DJ
Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. J Biol Chem (2009) 284: 10672-10683 |
Wang CK, Colgrave ML, Ireland DC, Kaas Q, Craik DJ
Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophys J. (2009) 97: 1471-1481 |
Trabi M, Mylne JS, Bharathi R, Sando L and Craik DJ
Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides. Org Biomol Chem (2009) 7: 2378-2388 |
Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K
Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12. Appl Environ Microbiol (2009) 75: 1552-1558 |
Martin-Visscher,L.A., Gong,X., Duszyk,M. and Vederas,J.C.
The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J. Biol. Chem. (2009) 284: 28674-28681 |
Göransson,U., Herrmann,A., Burman,R., Haugaard-Jönsson,L.M. and Rosengren,K.J.
The conserved glu in the cyclotide cycloviolacin O2 has a key structural role. Chembiochem (2009) 10: 2354-2360 |
Xiang B, Du GH, Wang XC, Zhang SX, Qin XY, Kong JQ, Cheng KD, Li YJ, Wang W
Elucidating the structure of two cyclotides of Viola tianshanica maxim by MALDI TOF/TOF MS analysis Yao Xue Xue Bao (2010) 45: 1402-1409 |
Tang J, Wang CK, Pan X, Yan He, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N
Isolation and Characterization of Bioactive Cyclotides from Viola labridorica Helvetica Chimica Acta (2010) 93: 2287-2295 |
Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N
Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides (2010) 31: 1434-1440 |
Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.
De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2010) 24: 599-604 |
Qin Q, McCallum EJ, Kaas Q, Suda J, Saska I, Craik DJ, Mylne JS.
Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics (2010) 11: 111-0 |
Puttamadappa,S.S., Jagadish,K., Shekhtman,A. and Camarero,J.A.
Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin. Angew. Chem. Int. Ed. Engl. (2010) 49: 7030-7034 |
Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ
Structural and biochemical characteristics of the cyclotide Kalata B5 from Oldenlandia affinis. Biopolymers (2010) 94: 647-658 |
Mylne JS, Wang CK, van der Weerden NL, Craik DJ
Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers (2010) 94: 635-646 |
Mehmood, R. and Malik, A.
Isolation and characterization of crotosparsamide, a new cyclic nonapeptide from Croton sparsiflorus Natural product communications (2010) 5: 1885-1888 |
Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D
Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers (2010) 94: 617-625 |
Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U
Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod (2010) 73: 1207-1213 |
Daly NL, Chen B, Nguyencong P, Craik DJ
Structure and Activity of the Leaf-Specific Cyclotide vhl-2. Australian Journal of Chemistry (2010) 63: 771-778 |
Colgrave ML, Poth AG, Kaas Q, Craik DJ
A new ‘era’ for cyclotide sequencing. Biopolymers: Peptide Science (2010) 94: 592-601 |
Burman, R., Svedlund, E., Felth, J., Hassan, S., Herrmann, A., Clark, R.J., Craik, D.J., Bohlin, L., Claeson, P., Göransson, U. and Gullbo, J
Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice Peptide Science (2010) 94: 626-634 |
Burman R, Gruber CW, Rizzardi K, Herrmann A, Craik DJ, Gupta MP, Göransson U
Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae. Phytochemistry (2010) 71: 13-20 |
Breuillin,F., Schramm,J., Hajirezaei,M., Ahkami,A., Favre,P., Druege,U., Hause,B., Bucher,M., Kretzschmar,T., Bossolini,E., Kuhlemeier,C., Martinoia,E., Franken,P., Scholz,U. and Reinhardt,D.
Phosphate systemically inhibits development of arbuscular mycorrhiza in Petunia hybrida and represses genes involved in mycorrhizal functioning. Plant J. (2010) 64: 1002-1017 |
Zenoni,S., D Agostino,N., Tornielli,G.B., Quattrocchio,F., Chiusano,M.L., Koes,R., Zethof,J., Guzzo,F., Delledonne,M., Frusciante,L., Gerats,T. and Pezzotti,M.
Revealing impaired pathways in the an11 mutant by high-throughput characterization of Petunia axillaris and Petunia inflata transcriptomes. Plant J. (2011) 68: 11-27 |
Yuan,C., Chen,L., Meehan,E.J., Daly,N., Craik,D.J., Huang,M. and Ngo,J.C.
Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. BMC Struct. Biol. (2011) 11: 30-0 |
Yeshak MY, Burman R, Asres K, Göransson U
Cyclotides from an Extreme Habitat: Characterization of Cyclic Peptides from Viola abyssinica of the Ethiopian Highlands J Nat Prod (2011) [ahead]: 0-0 |
Wong CT, Taichi M, Nishio H, Nishiuchi Y, Tam JP
Optimal Oxidative Folding of the Novel Antimicrobial Cyclotide from Hedyotis biflora Requires High Alcohol Concentrations. Biochemistry (2011) [ahead]: 0-0 |
Wang,C.K., Clark,R.J., Harvey,P.J., Rosengren,K.J., Cemazar,M. and Craik,D.J.
The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry (2011) 50: 4077-4086 |
Sando,L., Henriques,S.T., Foley,F., Simonsen,S.M., Daly,N.L., Hall,K.N., Gustafson,K.R., Aguilar,M.I. and Craik,D.J.
A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem (2011) 12: 2456-2462 |
Poth AG, Colgrave ML, Philip R, Kerenga B, Daly NL, Anderson MA, Craik DJ
Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 6: 345-355 |
Poth AG, Colgrave ML, Lyons RE, Daly NL, Craik DJ
Discovery of an unusual biosynthetic origin for circular proteins in legumes Proc Natl Acad Sci USA (2011) 108: 10127-10132 |
Ovesen,R.G., Nielsen,J. and Hansen,H.C.
Biomedicine in the environment: sorption of the cyclotide kalata B2 to montmorillonite, goethite, and humic acid. Environ. Toxicol. Chem. (2011) 30: 1785-1792 |
Nguyen,G.K., Zhang,S., Wang,W., Wong,C.T., Nguyen,N.T. and Tam,J.P.
Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J. Biol. Chem. (2011) 286: 44833-44844 |
Nguyen,G.K., Zhang,S., Nguyen,N.T., Nguyen,P.Q., Chiu,M.S., Hardjojo,A. and Tam,J.P.
Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J. Biol. Chem. (2011) 286: 24275-24287 |
Mylne JS, Colgrave ML, Daly NL, Chanson AH, Elliott AG, McCallum EJ, Jones A, Craik DJ.
Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol (2011) 7: 257-259 |
Masuda,Y., Ono,H., Kitagawa,H., Ito,H., Mu,F., Sawa,N., Zendo,T. and Sonomoto,K.
Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl. Environ. Microbiol. (2011) 77: 8164-8170 |
He,W., Chan,L.Y., Zeng,G., Daly,N.L., Craik,D.J. and Tan,N.
Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides (2011) 32: 1719-1723 |
Hashempour,H., Ghassempour,A., Daly,N.L., Spengler,B. and Römpp,A.
Analysis of cyclotides in Viola ignobilis by Nano liquid chromatography fourier transform mass spectrometry. Protein Pept. Lett. (2011) 18: 747-752 |
Contreras,J., Elnagar,A.Y., Hamm-Alvarez,S.F. and Camarero,J.A.
Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release (2011) 155: 134-143 |
Condie JA, Nowak G, Reed DW, Balsevich JJ, Reaney MJ, Arnison PG, Covello PS
The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors. Plant J (2011) 67: 682-90 |
Chan,L.Y., Gunasekera,S., Henriques,S.T., Worth,N.F., Le,S.J., Clark,R.J., Campbell,J.H., Craik,D.J. and Daly,N.L.
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 118: 6709-6717 |
Cascales,L., Henriques,S.T., Kerr,M.C., Huang,Y.H., Sweet,M.J., Daly,N.L. and Craik,D.J.
Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J. Biol. Chem. (2011) 286: 36932-36943 |
Burman,R., Strömstedt,A.A., Malmsten,M. and Göransson,U.
Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption. Biochim. Biophys. Acta (2011) 1808: 2665-2673 |
Borrero J, Brede DA, Skaugen M, Diep DB, Herranz C, Nes IF, Cintas LM, Hernández PE
Characterization of garvicin ML, a novel circular bacteriocin produced by Lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Appl Environ Microbiol (2011) 77: 369-373 |
Wong,C.T., Rowlands,D.K., Wong,C.H., Lo,T.W., Nguyen,G.K., Li,H.Y. and Tam,J.P.
Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angew. Chem. Int. Ed. Engl. (2012) 51: 5620-5624 |
Tischler,M., Nasu,D., Empting,M., Schmelz,S., Heinz,D.W., Rottmann,P., Kolmar,H., Buntkowsky,G., Tietze,D. and Avrutina,O.
Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations. Angew. Chem. Int. Ed. Engl. (2012) 51: 3708-3712 |
Poth,A.G., Mylne,J.S., Grassl,J., Lyons,R.E., Millar,A.H., Colgrave,M.L. and Craik,D.J.
Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae). J. Biol. Chem. (2012) 287: 27033-27046 |
Pinto,M.F., Fensterseifer,I.C., Migliolo,L., Sousa,D.A., de Capdville,G., Arboleda-Valencia,J.W., Colgrave,M.L., Craik,D.J., Magalhães,B.S., Dias,S.C. and Franco,O.L.
Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. J. Biol. Chem. (2012) 287: 134-147 |
Nguyen,G.K., Lim,W.H., Nguyen,P.Q. and Tam,J.P.
Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J. Biol. Chem. (2012) 287: 17598-17607 |
Mylne,J.S., Chan,L.Y., Chanson,A.H., Daly,N.L., Schaefer,H., Bailey,T.L., Nguyencong,P., Cascales,L. and Craik,D.J.
Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis. Plant Cell (2012) 24: 2765-2778 |
Eliasen,R., Daly,N.L., Wulff,B.S., Andresen,T.L., Conde-Frieboes,K.W. and Craik,D.J.
Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. J. Biol. Chem. (2012) 287: 40493-40501 |
Aboye,T.L., Ha,H., Majumder,S., Christ,F., Debyser,Z., Shekhtman,A., Neamati,N. and Camarero,J.A.
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J. Med. Chem. (2012) 55: 10729-10734 |
Zarrabi,M., Dalirfardouei,R., Sepehrizade,Z. and Kermanshahi,R.K.
Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human pathogenic bacteria. J. Appl. Microbiol. (2013) 115: 367-375 |
Nguyen,G.K., Lian,Y., Pang,E.W., Nguyen,P.Q., Tran,T.D. and Tam,J.P.
Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J. Biol. Chem. (2013) 288: 3370-3380 |
Koehbach,J., O Brien,M., Muttenthaler,M., Miazzo,M., Akcan,M., Elliott,A.G., Daly,N.L., Harvey,P.J., Arrowsmith,S., Gunasekera,S., Smith,T.J., Wray,S., Goransson,U., Dawson,P.E., Craik,D.J., Freissmuth,M. and Gruber,C.W.
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc. Natl. Acad. Sci. U.S.A (2013) 110: 21183-21188 |
Koehbach,J., Attah,A.F., Berger,A., Hellinger,R., Kutchan,T.M., Carpenter,E.J., Rolf,M., Sonibare,M.A., Moody,J.O., Wong,G.K., Dessein,S., Greger,H. and Gruber,C.W.
Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 100: 438-452 |
Ji,Y., Majumder,S., Millard,M., Borra,R., Bi,T., Elnagar,A.Y., Neamati,N., Shekhtman,A. and Camarero,J.A.
In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J. Am. Chem. Soc. (2013) 135: 11623-11633 |
Hashempour,H., Koehbach,J., Daly,N.L., Ghassempour,A. and Gruber,C.W.
Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. Amino Acids (2013) 44: 581-595 |
Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J.
Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew Chem Int Ed Engl (2014) 53: 11236-11241 |
Okinyo‐Owiti, D.P., Young, L., Burnett, P.G.G. and Reaney, M.J.
New flaxseed orbitides: Detection, sequencing, and 15N incorporation Peptide Science (2014) 102: 168-175 |
Mu,F., Masuda,Y., Zendo,T., Ono,H., Kitagawa,H., Ito,H., Nakayama,J. and Sonomoto,K.
Biological function of a DUF95 superfamily protein involved in the biosynthesis of a circular bacteriocin, leucocyclicin Q. J. Biosci. Bioeng. (2014) 117: 158-164 |
Jia,X., Kwon,S., Wang,C.I., Huang,Y.H., Chan,L.Y., Tan,C.C., Rosengren,K.J., Mulvenna,J.P., Schroeder,C.I. and Craik,D.J.
Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J Biol Chem (2014) 289: 6627-6638 |
Henriques,S.T., Huang,Y.H., Chaousis,S., Wang,C.K. and Craik,D.J.
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem (2014) 15: 1956-1965 |
Ding, X., Bai, D. and Qian, J
Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo Medicinal Chemistry Research (2014) 23: 1406-1413 |
Altei,W.F., Picchi,D.G., Abissi,B.M., Giesel,G.M., Flausino,O. Jr., Reboud-Ravaux,M., Verli,H., Crusca,E. Jr., Silveira,E.R., Cilli,E.M. and Bolzani,V.S.
Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: isolation, characterization, conformational studies and biological activity. Phytochemistry (2014) 107: 91-96 |
Zhang, J., Li, J., Huang, Z., Yang, B., Zhang, X., Li, D., Craik, D.J., Baker, A.J., Shu, W. and Liao, B.
Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of plant physiology (2015) 178: 17-26 |
Slazak, B., Jacobsson, E., Kuta, E. and Göransson, U.
Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae Phytochemistry (2015) 117: 527-536 |
Ravipati,A.S., Henriques,S.T., Poth,A.G., Kaas,Q., Wang,C.K., Colgrave,M.L. and Craik,D.J.
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. ACS Chem. Biol. (2015) 10: 2491-2500 |
Pinto,M.E., Batista,J.M. Jr., Koehbach,J., Gaur,P., Sharma,A., Nakabashi,M., Cilli,E.M., Giesel,G.M., Verli,H., Gruber,C.W., Blanch,E.W., Tavares,J.F., da Silva,M.S., Garcia,C.R. and Bolzani,V.S.
Ribifolin, an orbitide from Jatropha ribifolia, and its potential antimalarial activity. J. Nat. Prod. (2015) 78: 374-380 |
Mahatmanto, T., Mylne, J.S., Poth, A.G., Swedberg, J.E., Kaas, Q., Schaefer, H. and Craik, D.J.
The evolution of Momordica cyclic peptides. Molecular biology and evolution 32 (2015) 2: 392-405 |
Huang,Y.H., Henriques,S.T., Wang,C.K., Thorstholm,L., Daly,N.L., Kaas,Q. and Craik,D.J.
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep (2015) 5: 12974-0 |
Hu E, Wang D, Chen J, Tao X.
Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells Int J Clin Exp Med (2015) 8: 4059-4065 |
Hellinger,R., Koehbach,J., Soltis,D.E., Carpenter,E.J., Wong,G.K. and Gruber,C.W.
Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J. Proteome Res. (2015) 14: 4851-4862 |
Hellinger,R., Koehbach,J., Puigpinós,A., Clark,R.J., Tarragó,T., Giralt,E. and Gruber,C.W.
Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J. Nat. Prod. (2015) 78: 1073-1082 |
Cândido-Bacani, P.D.M., Figueiredo, P.D.O., Matos, M.D.F., Garcez, F.R. and Garcez, W.S.
Cytotoxic orbitide from the latex of Croton urucurana Journal of natural products (2015) 78: 2754-2760 |
Burnett, P.G.G., Jadhav, P.D., Okinyo-Owiti, D.P., Poth, A.G. and Reaney, M.J.
Glycine-containing flaxseed orbitides Journal of natural products (2015) 78: 681-688 |
Burman, R., Yeshak, M.Y., Larsson, S., Craik, D.J., Rosengren, K.J. and Göransson, U.
Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae Frontiers in plant science (2015) 6: 855-0 |
Wang, D., Chen, J., Zhu, J. and Mou, Y.
Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 |
Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkevičiūtė Z, Göransson U, Gründemann C, Schabbauer G, Gruber CW
Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis Proc Natl Acad Sci USA (2016) 113: 3960-3965 |
Strömstedt,A.A., Kristiansen,P.E., Gunasekera,S., Grob,N., Skjeldal,L. and Göransson,U.
Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. Biochim Biophys Acta (2016) 1858: 1317-1327 |
Serra,A., Hemu,X., Nguyen,G.K., Nguyen,N.T., Sze,S.K. and Tam,J.P.
A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-rich peptides. Sci Rep (2016) 6: 23005-0 |
Pinto, M.F., Silva, O.N., Viana, J.C., Porto, W.F., Migliolo, L., B. da Cunha, N., Gomes Jr, N., Fensterseifer, I.C., Colgrave, M.L., Craik, D.J. and Dias, S.C
Characterization of a Bioactive Acyclotide from Palicourea rigida Journal of natural products (2016) 79: 2767-2773 |
Niyomploy, P., Chan, L.Y., Poth, A.G., Colgrave, M.L., Sangvanich, P. and Craik, D.J.
Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq Peptide Science (2016) 106: 796-805 |
Nguyen KN, Nguyen GK, Nguyen PQ, Ang KH, Dedon PC, Tam JP
Immunostimulating and Gram-negative-specific Antibacterial Cyclotides from the Butterfly Pea Clitoria ternatea. FEBS J (2016) doi:10.1111/febs.13720: 0-0 |
Matsuura HN, Poth AG, Yendo AC, Fett-Neto AG, Craik DJ.
Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids. J Nat Prod. (2016) 79: 3006-3013 |
Glantz,S.T., Carpenter,E.J., Melkonian,M., Gardner,K.H., Boyden,E.S., Wong,G.K. and Chow,B.Y.
Functional and topological diversity of LOV domain photoreceptors. Proc. Natl. Acad. Sci. U.S.A. (2016) 113: 0-51 |
Gilding,E.K., Jackson,M.A., Poth,A.G., Henriques,S.T., Prentis,P.J., Mahatmanto,T. and Craik,D.J.
Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytol. (2016) 210: 717-730 |
Farhadpour,M., Hashempour,H., Talebpour,Z., A-Bagheri,N., Shushtarian,M.S., Gruber,C.W. and Ghassempour,A.
Microwave-assisted extraction of cyclotides from Viola ignobilis. Anal. Biochem. (2016) 497: 83-89 |
Esmaeili,M.A., Abagheri-Mahabadi,N., Hashempour,H., Farhadpour,M., Gruber,C.W. and Ghassempour,A.
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells. Fitoterapia (2016) 109: 162-168 |
Esmaeili, M. A., Abagheri-Mahabadi, N., Hashempour, H., Farhadpour, M., Gruber, C. W., & Ghassempour, A.
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells Fitoterapia (2016) 109: 162-168 |
dos S. Beirigo, P.J., Torquato, H.F., dos Santos, C.H., Carvalho, M.G.D., Castro, R.N., Paredes-Gamero, E.J., de Sousa Jr, P.T., Jacinto, M.J. and da Silva, V.C.
[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum Journal of natural products (2016) 79: 1454-1458 |
Cunha, N.B.D., Barbosa, A.E.A.D.D., de Almeida, R.G., Porto, W.F., Maximiano, M.R., Álvares, L.C.S., Munhoz, C.B.R., Eugênio, C.U.O., Viana, A.A.B., Franco, O.L. and Dias, S.C
Cloning and characterization of novel cyclotides genes from South American plants Peptide Science (2016) 106: 784-795 |
Burnett, P.G.G., Olivia, C.M., Okinyo-Owiti, D.P. and Reaney, M.J.T.
Orbitide composition of the flax Core collection (FCC) Journal of agricultural and food chemistry (2016) 64: 5197-5206 |
Attah,A.F., Hellinger,R., Sonibare,M.A., Moody,J.O., Arrowsmith,S., Wray,S. and Gruber,C.W.
Ethnobotanical survey of Rinorea dentata (Violaceae) used in South-Western Nigerian ethnomedicine and detection of cyclotides. J Ethnopharmacol (2016) 179: 83-91 |
Aboye, T., Meeks, C.J., Majumder, S., Shekhtman, A., Rodgers, K. and Camarero, J.A
Design of a MCoTI-based cyclotide with angiotensin (1-7)-like activity Molecules (2016) 21: 152-0 |
Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ
Structural and functional characterisation of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies Biopolymers (2016) : 0-0 |
Wang, D., Chen, J., Zhu, J. and Mou, Y.
Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 |
Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ.
Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. J Nat Prod. (2017) 80: 1522-1530 |
Nworu, C.S., Ejikeme, T.I., Ezike, A.C., Ndu, O., Akunne, T.C., Onyeto, C.A., Okpalanduka, P. and Akah, P.A.
Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) DC (Rubiaceae) African health sciences (2017) 17: 827-843 |
Narayani, M., Chadha, A. and Srivastava, S
Cyclotides from the indian medicinal plant Viola odorata (Banafsha): Identification and characterization Journal of natural products (2017) 80: 1972-1980 |
Lesniak, W.G., Aboye, T., Chatterjee, S., Camarero, J.A. and Nimmagadda, S.
In vivo evaluation of an engineered cyclotide as specific CXCR4 imaging reagent Chemistry–A European Journal (2017) 23: 14469-14475 |
Kirkpatrick, C.L., Broberg, C.A., McCool, E.N., Lee, W.J., Chao, A., McConnell, E.W., Pritchard, D.A., Hebert, M., Fleeman, R., Adams, J. and Jamil, A.
The “PepSAVI-MS” pipeline for natural product bioactive peptide discovery. Analytical chemistry (2017) 89: 1194-1201 |
Jayasena, A.S., Fisher, M.F., Panero, J.L., Secco, D., Bernath-Levin, K., Berkowitz, O., Taylor, N.L., Schilling, E.E., Whelan, J. and Mylne, J.S
Stepwise evolution of a buried inhibitor peptide over 45 My Molecular biology and evolution (2017) 34: 1505-1516 |
Hellinger, R., Thell, K., Vasileva, M., Muhammad, T., Gunasekera, S., Kümmel, D., Göransson, U., Becker, C.W. and Gruber, C.W
Chemical proteomics for target discovery of head-to-tail cyclized mini-proteins Frontiers in chemistry (2017) 5: 73-0 |
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W.
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology (2017) 8: 616-0 |
Zou, X.G., Hu, J.N., Li, J., Yang, J.Y., Du, Y.X., Yu, Y.F. and Deng, Z.Y
iCellular uptake of [1–9-NαC]-linusorb B2 and [1–9-NαC]-linusorb B3 isolated from flaxseed, and their antitumor activities in human gastric SGC-7901 cells Journal of Functional Foods (2018) 48: 692-703 |
Slazak, B., Kapusta, M., Strömstedt, A.A., Słomka, A., Krychowiak, M., Shariatgorji, M., Andrén, P.E., Bohdanowicz, J., Kuta, E. and Göransson, U.
How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Frontiers in plant science (2018) 9: 0-0 |
Ramalho, S.D., Pinto, M.E.F., Ferreira, D. and Bolzani, V.S.
Biologically active orbitides from the Euphorbiaceae family Planta medica (2018) 84: 558-567 |
Pinto,M.E.F., Najas,J.Z.G., Magalhães,L.G., Bobey,A.F., Mendonça,J.N., Lopes,N.P., Leme,F.M., Teixeira,S.P., Trovó,M., Andricopulo,A.D., Koehbach,J., Gruber,C.W., Cilli,E.M. and Bolzani,V.S.
Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. J. Nat. Prod. (2018) 81: 1203-1208 |
Parsley, N.C., Kirkpatrick, C.L., Crittenden, C.M., Rad, J.G., Hoskin, D.W., Brodbelt, J.S. and Hicks, L.M.
PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata Phytochemistry (2018) 152: 61-70 |
Niyomploy, P., Chan, L.Y., Harvey, P.J., Poth, A.G., Colgrave, M.L. and Craik, D.J
Discovery and characterization of cyclotides from Rinorea species Journal of natural products (2018) 81: 2512-2520 |
Kwon, S., Duarte, J.N., Li, Z., Ling, J.J., Cheneval, O., Durek, T., Schroeder, C.I., Craik, D.J. and Ploegh, H.L.
Targeted delivery of cyclotides via conjugation to a nanobody ACS chemical biology (2018) 13: 2973-2980 |
Keov, P., Liutkevičiūtė, Z., Hellinger, R., Clark, R.J. and Gruber, C.W.
Discovery of peptide probes to modulate oxytocin-type receptors of insects Scientific reports (2018) 8: 10020-0 |
Fisher, M.F., Zhang, J., Taylor, N.L., Howard, M.J., Berkowitz, O., Debowski, A.W., Behsaz, B., Whelan, J., Pevzner, P.A. and Mylne, J.S.
A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch Plant direct (2018) 2: 0-0 |
Bobey,A.F., Pinto,M.E.F., Cilli,E.M., Lopes,N.P. and Bolzani,V.D.S.
A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Med. (2018) 84: 947-952 |
Poth, A.G., Huang, Y.H., Le, T.T., Kan, M.W. and Craik, D.J.,
Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold International journal of pharmaceutics (2019) 565: 437-446 |
Parsley, Nicole C., Patric W. Sadecki, Conrad J. Hartmann, and Leslie M. Hicks
Viola “inconspicua” No More: An Analysis of Antibacterial Cyclotides Journal of natural products (2019) : 0-0 |
Fisher, M.F., Payne, C.D., Rosengren, K.J. and Mylne, J.S.
An orbitide from Ratibida columnifera seed containing 16 amino acid residues Journal of Natural Products (2019) 82: 2152-2158 |
Du J, Chan LY, Poth AG, Craik DJ
Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod. (2019) 82: 293-300 |
Zou, X.G., Li, J., Sun, P.L., Fan, Y.W., Yang, J.Y. and Deng, Z.Y.
Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells International Journal of Food Sciences and Nutrition (2020) : 1-11 |
Smithies, B.J., Huang, Y.H., Jackson, M.A., Yap, K., Gilding, E.K., Harris, K.S., Anderson, M.A. and Craik, D.J.,
Circular permutation of the native enzyme-mediated cyclization position in cyclotides ACS Chemical Biology (2020) 15: 962-969 |
Parsley,N.C., Williams,O.L. and Hicks,L.M.
Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions. J Am Soc Mass Spectrom (2020) 31: 1833-1843 |
Oguis, G.K., Gilding, E.K., Huang, Y.H., Poth, A.G., Jackson, M.A. and Craik, D.J.
Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions Industrial Crops and Products (2020) 147: 112214-0 |
Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.
Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of Papain Superfamily Cysteine Proteases. Pharmaceuticals (Basel) (2020) 14: 1-17 |
Kalmankar,N.V., Venkatesan,R., Balaram,P. and Sowdhamini,R.
Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis. Sci Rep (2020) 10: 12658-0 |
Fisher, M.F., Zhang, J., Berkowitz, O., Whelan, J. and Mylne, J.S.
Cyclic Peptides in Seed of Annona muricata Are Ribosomally Synthesized Journal of Natural Products. (2020) 83: 1167-1173 |
Du,Q., Huang,Y.H., Bajpai,A., Frosig-Jorgensen,M., Zhao,G. and Craik,D.J.
Evaluation of the <i>in Vivo</i> Aphrodisiac Activity of a Cyclotide Extract from <i>Hybanthus enneaspermus</i>. J Nat Prod (2020) : 0-0 |
Du,Q., Chan,L.Y., Gilding,E.K., Henriques,S.T., Condon,N.D., Ravipati,A.S., Kaas,Q., Huang,Y.H. and Craik,D.J.
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. J Biol Chem (2020) 295: 10911-10925 |
Du, J., Yap, K., Chan, L.Y., Rehm, F.B., Looi, F.Y., Poth, A.G., Gilding, E.K., Kaas, Q., Durek, T. and Craik, D.J.
A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors Nature communications (2020) 11: 1575-0 |
Dang,T.T., Chan,L.Y., Huang,Y.H., Nguyen,L.T.T., Kaas,Q., Huynh,T. and Craik,D.J.
Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. J Nat Prod (2020) 83: 1817-1828 |
Dancewicz, K., Slazak, B., Kiełkiewicz, M., Kapusta, M., Bohdanowicz, J. and Gabryś, B.
Behavioral and physiological effects of Viola spp. cyclotides on Myzus persicae (Sulz.) Journal of Insect Physiology (2020) 122: 104025-0 |
Rajendran,S., Slazak,B., Mohotti,S., Strömstedt,A.A., Göransson,U., Hettiarachchi,C.M. and Gunasekera,S.
Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis. Phytochemistry (2021) 187: 112749-0 |
Pinto,M.E.F., Chan,L.Y., Koehbach,J., Devi,S., Gründemann,C., Gruber,C.W., Gomes,M., Bolzani,V.S., Cilli,E.M. and Craik,D.J.
Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes. J Nat Prod (2021) 84: 81-90 |
Dang,T.T., Chan,L.Y., Tombling,B.J., Harvey,P.J., Gilding,E.K. and Craik,D.J.
In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis. J Nat Prod (2021) 84: 395-407 |
Aslam,L., Kaur,R., Sharma,V., Kapoor,N. and Mahajan,R.
Isolation and characterization of cyclotides from the leaves of Viola odorata L. using peptidomic and bioinformatic approach. 3 Biotech (2021) 11: 211-0 |
Contacts: